@jauhar123 | Posted 16 May. 2019
An efficient and effective route to 7-azaindole framework has been produced by one-*****, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, many aldehydes, and active methylene composites in ethanol or acetic acid at reflux.
Reactions involving tetronic acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione gave carbocyclic fused 7-azaindole, whereas Meldrum’s acid, benzoylacetonitrile, and malononitrile occurred in the highly substituted 7-azaindole derivatives, doing this strategy very useful in diversity-oriented synthesis.
Melting point: 105-107 °C(lit.)
Boiling point: 270 °C (753.1004 mmHg)
Density 1 .1151 (rough estimate)
refractive index 1.5500 (estimate)
Flash point: 270°C
storage temp. Refrigerator
color White to off-white
CAS DataBase Reference 271-63-6(CAS DataBase Reference)
Related Categories Azaindoles, Chemical Synthesis, Building Blocks, C7 to C9,
Heterocyclic Building Blocks,
7-Azaindoles have been widely studied for uses in biological examinations and imaging. Being isosteres of indoles, they have been the target of great synthetic efforts to investigate their potent pharmacological activities. 7-azaindoles are great blue emitters for organic LEDs (light emitting diodes). With a broad range of metal ions, they readily form coordination complexes, and their metal complexes present not only phosphorescence but also unusual and often unprecedented reactivity to C-H and C-X bonds