what is 7- Azaindole   

jauhar khan
@jauhar123 | Updated 14 Mar. 2019

7-Azaindole is a heterocyclic molecule the can be utilized as a pharmaceutical building block, starting material in a recent synthesis of azaserotonin.

Image result for Azaindole

Let's see it's purification methods and properties.

Purification Methods:

Recrystallize 7-Azaindole regularly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the pirate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]

7-Azaindole Properties:

  • Melting point:                          105-107 °C(lit.)

  • Boiling point:                           270 °C (753.1004 mmHg)

  • Density                                    1.1151 (rough estimate)

  • refractive index                        1.5500 (estimate)

  • Flashpoint:                                270°C

  • Storage temp.                            Refrigerator

  • form                                            Powder

  • color                                            White to off-white

  • BRN                                             109667

  • InChIKey                                       MVXVYAKCVDQRLW-UHFFFAOYSA-N

  • CAS DataBase Reference            271-63-6(CAS DataBase Reference)

  • NIST Chemistry Reference          1H-Pyrrolo[2,3-b]pyridine(271-63-6)

  • EPA Substance Registry               System 1H-Pyrrolo[2,3-b] pyridine(271-63-6)

Uses: Imidazolinone derivatives as CGRP receptor antagonists used in the treatment